G Protein-Coupled Receptor Heteromer Identification Technology: Identification and Profiling of GPCR Heteromers
نویسندگان
چکیده
منابع مشابه
G-protein-coupled receptor heteromer dynamics.
G-protein-coupled receptors (GPCRs) represent the largest family of cell surface receptors, and have evolved to detect and transmit a large palette of extracellular chemical and sensory signals into cells. Activated receptors catalyze the activation of heterotrimeric G proteins, which modulate the propagation of second messenger molecules and the activity of ion channels. Classically thought to...
متن کاملG-protein Coupled Receptor Dimerization
A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...
متن کاملIdentification and profiling of CXCR3-CXCR4 chemokine receptor heteromer complexes.
BACKGROUND AND PURPOSE The C-X-C chemokine receptors 3 (CXCR3) and C-X-C chemokine receptors 4 (CXCR4) are involved in various autoimmune diseases and cancers. Small antagonists have previously been shown to cross-inhibit chemokine binding to CXCR4, CC chemokine receptors 2 (CCR2) and 5 (CCR5) heteromers. We investigated whether CXCR3 and CXCR4 can form heteromeric complexes and the binding cha...
متن کاملUnderstanding the Added Value of G-Protein-Coupled Receptor Heteromers
G-protein-coupled receptors (GPCRs) constitute the most populated family of proteins within the human genome. Since the early sixties work on GPCRs and on GPCR-mediated signaling has led to a number of awards, the most recent being the Nobel Prize in Chemistry for 2012. The future of GPCRs research is surely based on their capacity for heteromerization. Receptor heteromers offer a series of cha...
متن کاملIdentification of novel G protein-coupled receptor-interacting proteins.
Biochemical and genetic methods utilizing G protein-coupled receptor fragments have been used successfully to identify G protein-coupled receptor-interacting proteins. As noted earlier, these methods may be unable to detect interactions that require certain conformations of the native receptor protein, but have nevertheless proven quite useful in expanding our understanding of receptor regulati...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: JALA: Journal of the Association for Laboratory Automation
سال: 2011
ISSN: 1535-5535
DOI: 10.1016/j.jala.2011.03.002